04 January 2011

M1 and M2 macrophages and the Herpes-virus family

Ah, the immune system.  It is what makes trillion-cell organisms possible.  Immune system cells actively patrol the body and attack bacteria, fugii, and parasites.  In the process, they often causing collateral damage to self-tissue.  The innate immune system compared to the adapted immune system is evolutionarily older and more prone to carpet bombing tactics to defeat pests. As such, when it doesn't operate properly, a broad list of symptoms can present.  The innate immune system actually has two roles: both fighting off foreign cells but also repairing damaged tissue.  When the innate immune system is always fighting and never repairing it leads to the state of chronic inflammation at the heart of many of the diseases that plague modern civilization, like diabetes, stroke, and heart disease.

What then determines which role an innate immune system cell body operates in at any given time and place in the body?  Let's look at monocytes/macrophages.

Monocytes are undifferentiated (i.e. unspecialized) immune system cells of the innate immune system that circulate in the bloodstream.  In response to chemical signals from the tissues adjacent to their blood vessels, they enter into the tissue to either fight infection or repair tissue damage.  When monocytes enter tissue, their gene expression causes them to become more specialized and they are then called macrophages (they can also become other immune system cells).  There are two basic phenotypes for macrophages, which are essentially the ying and yang of the macrophage community.
  • M1 macrophages are pro-inflammatory and fight infection.  They are the classical state for macrophages that you would find described in a textbook.  Primarily, they detect and fight foreign organisms (viruses, bacteria, and parasites).  They are characterized by the production of pro-inflammatory cytokines, chemicals which alert the other cell types of your immune system to react and destroy the invader (as well as adjacent 'self' cells). 
  • M2 macrophages are anti-inflammatory and repair tissue damage.  For example, when you exercise and your muscle tissue is damaged, it is M2 macrophages that infiltrate your muscle organs and affect the repairs [Tidball, 2010] after the initial M1 surge.  The characteristic cytokine of M2 macrophages is interleukin-10 (IL-10), which encourages other macrophages to enter the tissue and differentiate into M2 phenotype but also discourage the attention of cyto-toxic 'killer' cells from the lymphocyte family of the immune system.
The differentiation of macrophages, from M1 to M2, is not all that distinct and is generally though to represent the two extremes of a continuum.   My reading suggests macrophage populations can make the transition from one phenotype to the other, without die-offs.  This is probably a bad thing for chronic modern diseases, in that many of the diseases that are as a result of macrophage dysfunction occur when apoptosis (programmed cell death) is impeded.

One of the beneficial effects of eating a diet low in inflammatory factors (e.g. fructose, wheat, smoking) is that the overall levels of pro-inflammatory hormones, such as cortisol or interferon, are low so the transition from high M1 expression to high M2 expression can occur more rapidly. I strongly suspect this is why most people who transition to the paleo-diet are much better able to put on muscle mass. As the Tidball article indicates, chronic exercise is another no-no because it doesn't give enough time for the M2 macrophages to enter and affect repairs, so the muscle is always in an inflamed state.  

This doesn't, in general, appear to actually reduce the ability of the body to fight infectious disease, however.  This is probably because even though the overall inflammatory condition (as determined by circulating cortisol globally or cytokines locally) is low, it can easily spike when a foreign body attacks. On the other hand, actual conditions where adrenal functions are suppressed (i.e. Addison's disease), the immune system is hamstrung by the homonal milieu it finds itself in and the immune system doesn't function properly to defend against infection.  One hypothetical cause may be that the ratio of M2 to M1 is tilted in favour of M2 in adrenal insufficiency. 

One pathogen that is known to mess with the M1/M2 expression in macrophages is human cytomegalovirus (HCMV). HCMV basically takes M2 macrophages or undifferentiated monocytes and reprograms them to be more like M1 macrophages in some ways (Chan et al., 2009 and Chan et al., 2008).  Importantly, they do not become like M1 macrophages in that they continue to release interleukin-10, which discourages the adapted immune system from deploying 'killer' lymphocytes (natural-killer cells and T-cells) but encourages more M2 macrophages (red shirts, basically) and at the same time they up-regulate the production of protein filaments that make macrophages motile, so that they can better travel about and infect other organs. So let's all remember, whenever you have massive infiltrate of an organ by macrophages, you can probably bet there's too much IL-10 being produced.

To me the various  pathogens that excel at molecular mimicry to hide from the immune system seem to be playing quite the bogey-man role in a whole host of chronic diseases. These are principally the Herpes virus family (which also includes cytomegalovirus and the Epstein-Barr virus which has been linked to chronic fatigue syndrome) and the bacteria C. Pneumoniae, which has been linked to atherosclerosis and a whole host of other chronic diseases. Paul Jaminet over at Perfect Heath Diet has also been covering C. Pneumoniae in the brain,

It also seems a lot of disease symptoms occur when macrophages manifest some combination of the M1 and M2 state.  Consider that glucose in the blood is regulated by the liver predominately, so insulin resistance (aka metabolic syndrome) reflects failure of the liver to be able to do it's job.  Largely, this is blamed on 'inflammation' in the liver, e.g. alcholic and non-alcoholic fatty liver disease, but what does that mean exactly?

A review (Olefsky and Glass, 2010) states that macrophages in tissue that produce excessive quantities of tumour necrosis factor-α (TNF-α) and interleukin-16 (IL-16) (both pro-inflammatory cytokines), to the point that they are detectable in the blood. I like the following quotation from the review, as it really lays out the problem:
The discovery that adipose tissue from obese mice and humans is infiltrated with increased numbers of macrophages provided a major mechanistic advance into understanding how obesity propagates inflammation (4, 5). Adipose tissue contains bone marrow–derived macrophages, and the content of these macrophages tracks with the degree of obesity (4, 5, 31, 32). In some reports, greater than 40% of the total adipose tissue cell content from obese rodents and humans can be composed of macrophages, compared with ~10% in lean counterparts (32).
That nearly half of fat tissue mass is actually not fat cells, but immune system cells is kind of amazing to me. A very similar thing happens in liver disease. Now, reference #32 is a mouse study (Weisberg et al., 2006) but it in turn cites two other mice studies that are more pertinent (Weisberg et al., 2003 and Xu et al., 2003).  Both articles show that gene expression for various proteins that attract immune system cells are strongly up-regulated in the adipose tissue of fat mice.  The question is why?  Is it diet?  I suspect partially, but the revelations regarding what cytomegalovirus can do to macrophages makes me suspect latent pathogens are attracting macrophages as lambs to the slaughter. Are lab mice susceptible to chronic infections given their conditions and short lifespan?  Are these latent viruses transmitted from mother to infant?

The prevalence of immune system bodies in the adipose tissue of the obese mice illustrates an example of the, "diseases of civilization," being largely driven by dysfunction of the innate immune system, probably egged on by latent viral and bacterial infections and an unnatural diet.  The pieces of the puzzle are mostly there now and evidence will continue to accumulate until we have a better view of the whole picture.  Stop the sources of inflammation (i.e. immune system activation), give the immune system the substrates it needs to fight effectively, and the other symptoms will go away.

40 comments:

Robert McLeod said...

I accidently deleted a comment by J.A. Deep yesterday when going through the spam:

Great to see a post from you, Robert. I'm interested in the role of candidiasis in metabolic syndrome (and hence obesity). I note that mononuclear phagocytes, in some instances in the absence of other professional phagocytes such as neutrophils, also play an import role in resistance to systemic and mucosal candidiasis. Cite. Thoughts? Thanks, much.

Robert McLeod said...

Sigh... more spam to delete.

Sorry for the delay in replying Deep. The article you cited suggests neutrophils fail largely when they are defective, i.e. missing a certain gene, so that's not likely to affect the general population, just rare unfortunate individuals. That said, the *phils and macrophages tend to work together. The *phils are suicide shock troops of the innate immune system while the macrophages tend to mop up what's left.

The article you provided is pretty specific on mechanisms but doesn't go into much detail on the topic you are actually interested in.

J. A. Deep said...

Ah yes, I see now. May I ask about your conclusion that:

"The prevalence of immune system bodies in the adipose tissue of the obese mice illustrates an example of the, "diseases of civilization," being largely driven by dysfunction of the innate immune system, probably egged on by latent viral and bacterial infections and an unnatural diet. The pieces of the puzzle are mostly there now and evidence will continue to accumulate until we have a better view of the whole picture. Stop the sources of inflammation (i.e. immune system activation), give the immune system the substrates it needs to fight effectively, and the other symptoms will go away. "

Here, you suggest that "latent viral and bacterial infections and an unnatural diet" are "pieces of the puzzle."

I'm wondering if you've thought about whether latent fungal infections might be various pieces of this puzzle, too, especially where fungi opportunistically decompose an unnatural diet? While useful to decompose an unnatural diet, the fungal growths are also attacked by macrophages,* which (possibly?) leads to obesity, either directly or downstream, through immune system compromise that eventually leads to proliferation of the other latent pathogens, viral and bacterial?

Thanks again for the great post, and also for your follow up work!

* The fungi are also attacked, as you explained, by *phils.

STD Zip said...

The virus may stay where it entered the body or it can move through the blood, inside white blood cells, lymphatic vessels, or nerves.

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Dr Alamala said...



TESTIMONY OF HOW I GOT CURED FROM (HERPES SIMPLEX VIRUS) BY THE GREAT HEALER DOCTOR

Hello everyone my name is sandra I am here to testify of the great work Dr ALAMALA did in my life with the help of his herbal traditional medicine. I have been suffering from Herpes since 2015 and ever since then I have been looking for solutions on how to cure it. I have being to different hospitals but I discovered none of them was working out for me that I was just wasting money. So I decided to live everything to God, then I was taking my medications to sustain my life and reduce the pains. So on this particular Sunday morning after coming back from service I sat down and begin to ask myself questions, then my phone rang behold it was my sister calling which I answered the call and she started telling me that a friend of hers who has been suffering from same herpes has just been cured by Dr ALAMALA the herbal medicine man. Then I was over whelmed, even though I was a little bit confused so she encourage me to also give Dr ALAMALA a trial and see for myself then I told her to help me get his contact and forward them to me, So immediately she got the contact of Dr ALAMALA and send them to me, immediately I contacted Dr ALAMALA and he told me everything I needed to do to enable me get the herbs for my medications and immediately i did that which he instructed me to do without wasting anytime. And here I am today sound and healthy without any symptoms of herps or any sickness in my body system. And he also told me that there is no sickness on this planet earth that doesn’t have a cure that with the help of herbs he can cure any sickness or disease you can ever think off. So if you are suffering from HERPES or any other sickness or disease and you need a cure you can also contact Dr ALAMALA with this Email Address at (dr.alamalaspiritualtemple@gmail.com) so you can also receive your healing and share your testimony.

Dr Alamala said...



TESTIMONY OF HOW I GOT CURED FROM (HERPES SIMPLEX VIRUS) BY THE GREAT HEALER DOCTOR

Hello everyone my name is sandra I am here to testify of the great work Dr ALAMALA did in my life with the help of his herbal traditional medicine. I have been suffering from Herpes since 2015 and ever since then I have been looking for solutions on how to cure it. I have being to different hospitals but I discovered none of them was working out for me that I was just wasting money. So I decided to live everything to God, then I was taking my medications to sustain my life and reduce the pains. So on this particular Sunday morning after coming back from service I sat down and begin to ask myself questions, then my phone rang behold it was my sister calling which I answered the call and she started telling me that a friend of hers who has been suffering from same herpes has just been cured by Dr ALAMALA the herbal medicine man. Then I was over whelmed, even though I was a little bit confused so she encourage me to also give Dr ALAMALA a trial and see for myself then I told her to help me get his contact and forward them to me, So immediately she got the contact of Dr ALAMALA and send them to me, immediately I contacted Dr ALAMALA and he told me everything I needed to do to enable me get the herbs for my medications and immediately i did that which he instructed me to do without wasting anytime. And here I am today sound and healthy without any symptoms of herps or any sickness in my body system. And he also told me that there is no sickness on this planet earth that doesn’t have a cure that with the help of herbs he can cure any sickness or disease you can ever think off. So if you are suffering from HERPES or any other sickness or disease and you need a cure you can also contact Dr ALAMALA with this Email Address at (dr.alamalaspiritualtemple@gmail.com) so you can also receive your healing and share your testimony.

Unknown said...

I was cured of HIV with the use of natural herbs. My name is Sarah and am from US. I love herbs so much. Most times, injection and drugs are just a waste of time. I was cured 8months ago, i suffered from HIV for 13yrs but with the help of DR. Baba Ogu herbal medicine, i was cured within few weeks of drinking the herbs he sent to me through courier delivery service. This same doctor also cured my Aunt from herpes, as soon as i heard she had herpes, i quickly refer her to Dr. Baba Ogu and she was cured too after drinking his herbs.I have referred more than 15 persons to Dr. Baba Ogu and they were all cured from their various illness. Have you taken herbs before?. You have spent so much money on drugs,injections,surgeries etc and yet you have no good result to show for it. Contact Dr. Baba Ogu now, he is a herbalist doctor, i assured you of a cure if you drink his natural herbs. Dr Baba Ogu have herbs that cures Hiv, Herpes, diabetics, asthma, hepatitis,HBP, STD, cancer, chronic, etc. He is also a spell caster, he can cast a spell to bring back your EX lover. Contact Dr. Baba Ogu through his Email address on: drbabaogu@gmail.com or WHATSAP/CALL him on +2348137291215. Share the good news to others once you are cured. Thank you.

Joyice Ken said...

I was haven herpes 2 on my private part. I have had them for about 2 and a bit years. I am so scared what my mates are going to says if there should fined out i have herpes on my private part and due to the virus my girlfriend broke up with me. I have been to the Doctors 9 times to get it treated. They all come back. I have been using Tee Tree Oil and Wartner (You freeze them at home) and they seem to be keeping the smaller herpes small but they can't seem to treat the larger ones. They don't get any bigger, but then they can't shrink as much. They get smaller a little part at a time. At least they are getting smaller! As soon as I see a new herpes appearing, then I treat it. At the moment I have been using Tee Tree twice a week and then using Wartner every 2 weeks. I was wondering if there was any other information about how to get rid of it. I am only a teenager and I hate it most when it get pi-chins me to scratch it, it get sweets when scratching it most times! I want to get rid of it so bad! DR.OBA website has been a huge help and has helped me realize a lot more about me and my family of genital herpes! so that was when i switch for natural remedy to see if there could be any help by herbal remedy, i search and i saw a great posts by Sarah devise adebayo ehijactor and shanttel Merritt on about the great herbal doctor that get them rid of there disease infection. and this great herbal doctor was called DR.OBA so that was when i contacted him for my own treatment and he prepared me some herbs which i takes for some couples of days, and i take it as he says before i am to no me and my family was perfectly cure for it and never experience it again. please friends if you have herpes virus and you really wants to get rid of it, please contact this great DR.OBA for herbal treatment and you will get rid of it. EMAIL. drobaspellhome902@gmail.com

cell phone contact +2348154692747
his whatsapp contact is +2348154692747


THANK TO YOU ALL FOR YOUR TIME OF READY MY TESTIMONY AND MOST ESPECIALLY YOU DR. OBA I PRAY TO GOD TO NEVER LET ME AND MY FAMILY FORGET YOU IN OUR LIFE'S

Greg Thomas said...

Medical scientists have discovered a new way to battle HIV AIDS by using a man called Dr itua
MY NAME IS Greg Thomas.I SAW A COMMENT ON POSITIVE BLOGS AND I WILL LOVE TO TELL EVERY BODY HOW MY STATUS CHANGES TO NEGATIVE and i got cured,
AND AM NOW A LIVING WITNESS OF IT AND I THINK ITS A SHAME ON ME IF I DON'T SHARE THIS LOVELY STORY WITH OTHER PEOPLE INFECTED WITH THIS DEADLY VIRUS.
HIV HAS BEEN ONGOING IN MY FAMILY, I LOST BOTH PARENTS TO HIV. AND IT IS SO MUCH PAIN I'VE NOT BEEN ABLE TO GET OVER..
AS WE ALL KNOW MEDICALLY THERE IS NO SOLUTION TO IT..AND MEDICATION IS VERY EXPENSIVE..SO SOMEONE INTRODUCED ME TO A HERBAL PRACTITIONER IN AFRICA..
I HAD A JOB THERE TO EXECUTE SO I TOOK TIME TO CHECK OUT ON HIM.I SHOWED HIM ALL MY TESTS AND RESULTS..
I WAS ALREADY DISORGANIZED WITH HIV AND IT WAS ALREADY TAKING ITS TOWL ON ME..
I HAD SPENT THOUSANDS OF DOLLARS SO I DECIDED TO TRY HIM OUT ALTHOUGH I DID'NT BELIEVE IN IT,
I WAS JUST TRYING IT OUT OF FRUSTRATION? AND AFTER 14 DAYS, HE TOLD ME TO GO FOR A MEDICAL TEST.
AND YOU WON'T BELIEVE THAT 5 DIFFERENT DOCTORS CONFIRMED IT THAT AM NEGATIVE..IT WAS LIKE A DREAM,,I NEVER BELIEVE HIV HAS CURE..AM NOW NEGATIVE,,
AM A LIVING WITNESS..I DON'T KNOW HOW TO THANK THIS MAN? I JUST WANT TO HELP OTHERS IN ANY WAY I CAN..
I HAVE JOINED MANY FORUMS AND HAVE POSTED THIS TESTIMONIES AND ALOT OF PEOPLE HAS MAIL AND CALLED THIS MAN ON PHONE AND AFTER 14 DAYS THEY ALL CONFIRMED NEGATIVE..
BBC NEWS TOOK IT LIVE AND EVERY EVERYBODY SAW IT AND ITS NOW OUT IN PAPERS AND MAGAZINES THAT THERE IS A HERBAL CURE FOR HIV AND ALL WITH THE HELP OF THIS MAN,,
IF YOU WISH TAKE IT OR NOT..GOD KNOWS I HAVE TRIED MY BEST. ABOUT 28 PEOPLE HAVE BEEN CONFIRMED NEGATIVE THROUGH THE HERBAL CURE OF DR ITUA
AND THEY SEND MAILS TO THANKS ME AFTER THEY HAVE BEEN CONFIRMED NEGATIVE,,THIS MAN IS REAL..DON'T MISS THIS CHANCE,,HIV IS A DEADLY VIRUS,,GET RID OF IT NOW..
If there is anyone who has similar problem and still looking for a way out, his email still remains drituaherbalcenter@gmail.com or call or whatsapp him on +2348149277967
DOCTOR ITUA CAN AS WELL CURE THE FOLLOWING DISEASE:-
1. HIV/AIDS
2. HERPES
3. CANCER
4. ALS
5. Hepatitis B
6. Diabetes

Thanks Moderators

ramsey said...

I THOUGHT THE PHYSICIANS SAY NO CURE FOR HIV/AIDS?, I AM TELLING YOU TODAY THAT DR. UNAGBUNA CURED MY HIV/AIDS WITH HIS HERBAL MEDICINE AND ONCE YOU GET CURED YOU ARE FOREVER CURED IT IS NEVER REVERSABLE.

MY NAME IS RAMSEY JOHN DONNE FROM THE UNITED STATE OF AMERICA,I AM USING THIS GREAT OPPORTUNITY TO SAVE LIFE BY SHARING MY TESTIMONY THAT THERE IS A CURE FOR HIV/AIDS BECAUSE I AM A LIVING TESTIMONY,I SUFFERED FOR HIV/AIDS FOR GOOD ONE YEAR AND TWO MONTHS AFTER LOOSING HOPE THAT I CAN NEVER GET THE CURE BEACAUSE THE DOCTORS SAID THERE IS NO CURE FOR IT,BUT THANKS BEEN TO THIS GREAT MAN CALLED DR UNAGBUNA WHOM I READ A TESTIMONY ABOUT ON HOW HE CURED HIV/AIDS WITH HIS HERBAL MEDICINE,I NEVER BELIEVE THIS BUT I DECIDED TO CONTACT HIM THROUGH THE STATED EMAIL,(unagbunaherbalcure@gmail.com) and he send to me a herbal medicine and ask me to drink and bath with the herbal medicine for one 3 weeks but to my greatest surprises, i went for a medical test after two weeks and my status was negetive till today i cant keep sharing this testimony please brothers and sisters there is a cure to hiv/aids, contact this man for what ever you are going through, what ever sickness you are suffering from, like
(1) CANCER,
(2) DIABETES,
(3) HIV&AIDS,
(4) URINARY TRACT INFECTION,
(5) CANCER,
(6) IMPOTENCE,
(7) BARENESS/INFERTILITY
(8) DIARRHEA
(9) ASTHMA
(10)SIMPLEX HERPES AND GENITAL HERPES
11) HE ALSO HAVE SPELL TO BRING BACK YOUR EX
hiv/aids,perkinsons disease, ALS,CANCERS,HERPES. contact him with his email via (unagbunaherbalcure@gmail.com) or call him through the following contact on +2348112139676

ramsey said...

I THOUGHT THE PHYSICIANS SAY NO CURE FOR HIV/AIDS?, I AM TELLING YOU TODAY THAT DR. UNAGBUNA CURED MY HIV/AIDS WITH HIS HERBAL MEDICINE AND ONCE YOU GET CURED YOU ARE FOREVER CURED IT IS NEVER REVERSABLE.

MY NAME IS RAMSEY JOHN DONNE FROM THE UNITED STATE OF AMERICA,I AM USING THIS GREAT OPPORTUNITY TO SAVE LIFE BY SHARING MY TESTIMONY THAT THERE IS A CURE FOR HIV/AIDS BECAUSE I AM A LIVING TESTIMONY,I SUFFERED FOR HIV/AIDS FOR GOOD ONE YEAR AND TWO MONTHS AFTER LOOSING HOPE THAT I CAN NEVER GET THE CURE BEACAUSE THE DOCTORS SAID THERE IS NO CURE FOR IT,BUT THANKS BEEN TO THIS GREAT MAN CALLED DR UNAGBUNA WHOM I READ A TESTIMONY ABOUT ON HOW HE CURED HIV/AIDS WITH HIS HERBAL MEDICINE,I NEVER BELIEVE THIS BUT I DECIDED TO CONTACT HIM THROUGH THE STATED EMAIL,(unagbunaherbalcure@gmail.com) and he send to me a herbal medicine and ask me to drink and bath with the herbal medicine for one 3 weeks but to my greatest surprises, i went for a medical test after two weeks and my status was negetive till today i cant keep sharing this testimony please brothers and sisters there is a cure to hiv/aids, contact this man for what ever you are going through, what ever sickness you are suffering from, like
(1) CANCER,
(2) DIABETES,
(3) HIV&AIDS,
(4) URINARY TRACT INFECTION,
(5) CANCER,
(6) IMPOTENCE,
(7) BARENESS/INFERTILITY
(8) DIARRHEA
(9) ASTHMA
(10)SIMPLEX HERPES AND GENITAL HERPES
11) HE ALSO HAVE SPELL TO BRING BACK YOUR EX
hiv/aids,perkinsons disease, ALS,CANCERS,HERPES. contact him with his email via (unagbunaherbalcure@gmail.com) or call him through the following contact on +2348112139676

ramsey said...

I THOUGHT THE PHYSICIANS SAY NO CURE FOR HIV/AIDS?, I AM TELLING YOU TODAY THAT DR. UNAGBUNA CURED MY HIV/AIDS WITH HIS HERBAL MEDICINE AND ONCE YOU GET CURED YOU ARE FOREVER CURED IT IS NEVER REVERSABLE.

MY NAME IS RAMSEY JOHN DONNE FROM THE UNITED STATE OF AMERICA,I AM USING THIS GREAT OPPORTUNITY TO SAVE LIFE BY SHARING MY TESTIMONY THAT THERE IS A CURE FOR HIV/AIDS BECAUSE I AM A LIVING TESTIMONY,I SUFFERED FOR HIV/AIDS FOR GOOD ONE YEAR AND TWO MONTHS AFTER LOOSING HOPE THAT I CAN NEVER GET THE CURE BEACAUSE THE DOCTORS SAID THERE IS NO CURE FOR IT,BUT THANKS BEEN TO THIS GREAT MAN CALLED DR UNAGBUNA WHOM I READ A TESTIMONY ABOUT ON HOW HE CURED HIV/AIDS WITH HIS HERBAL MEDICINE,I NEVER BELIEVE THIS BUT I DECIDED TO CONTACT HIM THROUGH THE STATED EMAIL,(unagbunaherbalcure@gmail.com) and he send to me a herbal medicine and ask me to drink and bath with the herbal medicine for one 3 weeks but to my greatest surprises, i went for a medical test after two weeks and my status was negetive till today i cant keep sharing this testimony please brothers and sisters there is a cure to hiv/aids, contact this man for what ever you are going through, what ever sickness you are suffering from, like
(1) CANCER,
(2) DIABETES,
(3) HIV&AIDS,
(4) URINARY TRACT INFECTION,
(5) CANCER,
(6) IMPOTENCE,
(7) BARENESS/INFERTILITY
(8) DIARRHEA
(9) ASTHMA
(10)SIMPLEX HERPES AND GENITAL HERPES
11) HE ALSO HAVE SPELL TO BRING BACK YOUR EX
hiv/aids,perkinsons disease, ALS,CANCERS,HERPES. contact him with his email via (unagbunaherbalcure@gmail.com) or call him through the following contact on +2348112139676

ramsey said...

I THOUGHT THE PHYSICIANS SAY NO CURE FOR HIV/AIDS?, I AM TELLING YOU TODAY THAT DR. UNAGBUNA CURED MY HIV/AIDS WITH HIS HERBAL MEDICINE AND ONCE YOU GET CURED YOU ARE FOREVER CURED IT IS NEVER REVERSABLE.

MY NAME IS RAMSEY JOHN DONNE FROM THE UNITED STATE OF AMERICA,I AM USING THIS GREAT OPPORTUNITY TO SAVE LIFE BY SHARING MY TESTIMONY THAT THERE IS A CURE FOR HIV/AIDS BECAUSE I AM A LIVING TESTIMONY,I SUFFERED FOR HIV/AIDS FOR GOOD ONE YEAR AND TWO MONTHS AFTER LOOSING HOPE THAT I CAN NEVER GET THE CURE BEACAUSE THE DOCTORS SAID THERE IS NO CURE FOR IT,BUT THANKS BEEN TO THIS GREAT MAN CALLED DR UNAGBUNA WHOM I READ A TESTIMONY ABOUT ON HOW HE CURED HIV/AIDS WITH HIS HERBAL MEDICINE,I NEVER BELIEVE THIS BUT I DECIDED TO CONTACT HIM THROUGH THE STATED EMAIL,(unagbunaherbalcure@gmail.com) and he send to me a herbal medicine and ask me to drink and bath with the herbal medicine for one 3 weeks but to my greatest surprises, i went for a medical test after two weeks and my status was negetive till today i cant keep sharing this testimony please brothers and sisters there is a cure to hiv/aids, contact this man for what ever you are going through, what ever sickness you are suffering from, like
(1) CANCER,
(2) DIABETES,
(3) HIV&AIDS,
(4) URINARY TRACT INFECTION,
(5) CANCER,
(6) IMPOTENCE,
(7) BARENESS/INFERTILITY
(8) DIARRHEA
(9) ASTHMA
(10)SIMPLEX HERPES AND GENITAL HERPES
11) HE ALSO HAVE SPELL TO BRING BACK YOUR EX
hiv/aids,perkinsons disease, ALS,CANCERS,HERPES. contact him with his email via (unagbunaherbalcure@gmail.com) or call him through the following contact on +2348112139676

ramsey said...

I THOUGHT THE PHYSICIANS SAY NO CURE FOR HIV/AIDS?, I AM TELLING YOU TODAY THAT DR. UNAGBUNA CURED MY HIV/AIDS WITH HIS HERBAL MEDICINE AND ONCE YOU GET CURED YOU ARE FOREVER CURED IT IS NEVER REVERSABLE.

MY NAME IS RAMSEY JOHN DONNE FROM THE UNITED STATE OF AMERICA,I AM USING THIS GREAT OPPORTUNITY TO SAVE LIFE BY SHARING MY TESTIMONY THAT THERE IS A CURE FOR HIV/AIDS BECAUSE I AM A LIVING TESTIMONY,I SUFFERED FOR HIV/AIDS FOR GOOD ONE YEAR AND TWO MONTHS AFTER LOOSING HOPE THAT I CAN NEVER GET THE CURE BEACAUSE THE DOCTORS SAID THERE IS NO CURE FOR IT,BUT THANKS BEEN TO THIS GREAT MAN CALLED DR UNAGBUNA WHOM I READ A TESTIMONY ABOUT ON HOW HE CURED HIV/AIDS WITH HIS HERBAL MEDICINE,I NEVER BELIEVE THIS BUT I DECIDED TO CONTACT HIM THROUGH THE STATED EMAIL,(unagbunaherbalcure@gmail.com) and he send to me a herbal medicine and ask me to drink and bath with the herbal medicine for one 3 weeks but to my greatest surprises, i went for a medical test after two weeks and my status was negetive till today i cant keep sharing this testimony please brothers and sisters there is a cure to hiv/aids, contact this man for what ever you are going through, what ever sickness you are suffering from, like
(1) CANCER,
(2) DIABETES,
(3) HIV&AIDS,
(4) URINARY TRACT INFECTION,
(5) CANCER,
(6) IMPOTENCE,
(7) BARENESS/INFERTILITY
(8) DIARRHEA
(9) ASTHMA
(10)SIMPLEX HERPES AND GENITAL HERPES
11) HE ALSO HAVE SPELL TO BRING BACK YOUR EX
hiv/aids,perkinsons disease, ALS,CANCERS,HERPES. contact him with his email via (unagbunaherbalcure@gmail.com) or call him through the following contact on +2348112139676

Unknown said...

I was haven Herpes 2 spreading all over my body even on my private part two. i contacted Dr.Ojie for helping me to cure my Herpes virus problem which i have been going through for the past 3 years, i really tried many prescribed medicine but could not work for me till i was privileged to meet this Dr.Ojie who helped me with a positive solution and cure my herpes with herbal remedies. You can also be cured if you are suffering of any types of HERPES or diseases, by contacting Dr.Ojie via drojiespelltemple@gmail.com cell phone contact +2348105074556

ramsey said...

I THOUGHT THE PHYSICIANS SAY NO CURE FOR HIV/AIDS?, I AM TELLING YOU TODAY THAT DR. UNAGBUNA CURED MY HIV/AIDS WITH HIS HERBAL MEDICINE AND ONCE YOU GET CURED YOU ARE FOREVER CURED IT IS NEVER REVERSABLE.

MY NAME IS RAMSEY JOHN DONNE FROM THE UNITED STATE OF AMERICA,I AM USING THIS GREAT OPPORTUNITY TO SAVE LIFE BY SHARING MY TESTIMONY THAT THERE IS A CURE FOR HIV/AIDS BECAUSE I AM A LIVING TESTIMONY,I SUFFERED FOR HIV/AIDS FOR GOOD ONE YEAR AND TWO MONTHS AFTER LOOSING HOPE THAT I CAN NEVER GET THE CURE BEACAUSE THE DOCTORS SAID THERE IS NO CURE FOR IT,BUT THANKS BEEN TO THIS GREAT MAN CALLED DR UNAGBUNA WHOM I READ A TESTIMONY ABOUT ON HOW HE CURED HIV/AIDS WITH HIS HERBAL MEDICINE,I NEVER BELIEVE THIS BUT I DECIDED TO CONTACT HIM THROUGH THE STATED EMAIL,(unagbunaherbalcure@gmail.com) and he send to me a herbal medicine and ask me to drink and bath with the herbal medicine for one 3 weeks but to my greatest surprises, i went for a medical test after two weeks and my status was negetive till today i cant keep sharing this testimony please brothers and sisters there is a cure to hiv/aids, contact this man for what ever you are going through, what ever sickness you are suffering from, like
(1) CANCER,
(2) DIABETES,
(3) HIV&AIDS,
(4) URINARY TRACT INFECTION,
(5) CANCER,
(6) IMPOTENCE,
(7) BARENESS/INFERTILITY
(8) DIARRHEA
(9) ASTHMA
(10)SIMPLEX HERPES AND GENITAL HERPES
11) HE ALSO HAVE SPELL TO BRING BACK YOUR EX
hiv/aids,perkinsons disease, ALS,CANCERS,HERPES. contact him with his email via (unagbunaherbalcure@gmail.com) or call him through the following contact on +2348112139676

Unknown said...

I was haven Herpes 2 spreading all over my body even on my private part two. i contacted Dr.Ojie for helping me to cure my Herpes virus problem which i have been going through for the past 3 years, i really tried many prescribed medicine but could not work for me till i was privileged to meet this Dr.Ojie who helped me with a positive solution and cure my herpes with herbal remedies. You can also be cured if you are suffering of any types of HERPES or diseases, by contacting Dr.Ojie via drojiespelltemple@gmail.com cell phone contact +2348105074556

jessica allen said...


Happiness is all i see now I never thought that I will be cured from HERPES virus again. I have been suffering from a deadly disease (HERPES) for the past 3 years now, I had spent a lot of money going from one places to another, from churches to churches, hospitals have been my home every day residence. Constant checks up have been my hobby not until this faithful day, I was searching through the internet, I saw a testimony on how DR Aba helped someone in curing his HERPES disease, quickly I copied his email which is dr.abaherbalhome@gmail.com just to give him a test I spoke to him, he asked me to do some certain things which I did, he told me that he is going to provide the herbal cure to me, which he did, then he asked me to go for medical checkup after some days after using the herbal cure, behold I was free from the deadly disease, he only asked me to post the testimony through the whole world, faithfully am doing it now, please brothers and sisters, he is great, I owe him in return. if you are having a similar problem just email him on ( dr.abaherbalhome@gmail.com ) or you can whatsApp his mobile number on +2348107155060

Mary Hanson said...

Thank you Dr. Okuns, your herbal medicine is a good remedy for herpes cure, and Removing Warts! You can contact Dr. Okuns via E-mail: herbal.home247@yahoo.com for any types of diseases solutions or WhatsApp him on: +2348078467513

My name is Mary Hanson, am from United State. I want the general public
to know how this great man called Dr. Okuns cure me and my sister from GENITAL HERPES with the herbal medicine gotten from him, he cures other diseases too like STD, SYPHILIS, My own was worst I have suffered for Human papilloma virus HPV) for 2years he cure me too, herbal is a great medication. he have a medicine that is 100% percent assured to cure any type of disease and you don't need to spend so much money anymore . I want you to contact Dr. Okuns on: herbal.home247@yahoo.com My family is now a brand new one, so stop your worries and go get your herbal medicine now to get your family free from deadly disease. Once again thanks to Dr. Okuns you can contact him now via phone number: +2348078467513 or email him on: herbal.home247@yahoo.com

melisa white said...

I am really happy that i have been cured from (HERPES SIMPLEX VIRUS) with the herbal medicine of DR ADEMUSHI, i have been suffering from this disease for the past 2 years and 7 mouth without solution until i came across the email of this doctor who have cure so many people with his herbal medicine, i also choose to give him a chance to help me and my husband, he told me what to do and i kindly did it, and he gave us his herbal medicine and direct me on how to use it, i also follow his instructions for use and he ask us to go for a check up after 1 week and 4days which i did, to my greatest surprise our result came out as negative, we are really happy that there is someone like this doctor who is ready to help anytime any day. To all the readers and viewers that is doubting this testimony stop doubting it and contact this doctor if you really have one and see if he will not actually help you. i am not a stupid woman that i will come out to the public and start saying what someone have not done for me and i know that there are some people out there who are really suffering and hurting their family just because of these diseases so you can to mail him on drademushiherbalhome@hotmail.com he also told me that he has cure for these diseases listed below:
.DIABETES
.CANCER
.HEPATITIS
.HIV/AIDS E.T.C.

jessica allen said...


Happiness is all i see now I never thought that I will be cured from HERPES virus again. I have been suffering from a deadly disease (HERPES) for the past 3 years now, I had spent a lot of money going from one places to another, from churches to churches, hospitals have been my home every day residence. Constant checks up have been my hobby not until this faithful day, I was searching through the internet, I saw a testimony on how DR Aba helped someone in curing his HERPES disease, quickly I copied his email which is dr.abaherbalhome@gmail.com just to give him a test I spoke to him, he asked me to do some certain things which I did, he told me that he is going to provide the herbal cure to me, which he did, then he asked me to go for medical checkup after some days after using the herbal cure, behold I was free from the deadly disease, he only asked me to post the testimony through the whole world, faithfully am doing it now, please brothers and sisters, he is great, I owe him in return. if you are having a similar problem just email him on ( dr.abaherbalhome@gmail.com ) or you can whatsApp his mobile number on +2348107155060

Cudu Orela said...

God bless Dr UZOYA for helping me cure my Herpes HSV 1. Brethren, i have suffered Herpes HSV 1 for a long period of time, i have tried so many remedy, but known seems to work. But i had to contact with a herbal doctor who i saw so many people testifying on how they were all cured of their various disease and viruses by this doctor. So i explained my entire problem to him, and he promised to cure me. So i gave him all benefit of doubt, and behold he prepared the herbal mixture, and send it to me in my country. Today, i am proud to say i am Herpes HSV 1 FREE,So in case you are out there suffering from Herpes and other diseases or virus, i want to tell you to quickly contact: Dr UZOYA for your cure. His email is [uzoyaherbalhome@gmail.com] you can also WhatsApp him on his telephone number +2348151098492

Angela Jones said...

Hi Friends i am so glad to writing this article today to tell the world how Dr Unuareghe cured my HSV VIRUS,i have been detected with HSV-1 AND HSV-2 since five years ago, ever since then my life has been in complete bizarre and agony,i have used so many drugs that was prescribed to me by several doctors,but it didn't cure my HSV VIRUS neither did it reduce the pain,until a certain i was checking for solution in the internet,then miraculously came across Dr Unuareghe the powerful herbalist that cure numerous individuals HSV-1 AND HSV-2 INFECTION,then i contacted his email: dr.unuareghecuringhome@gmail.com i explained everything to him and prepared a cure that cure my HSV-1 AND HSV-2 disease totally after receiving his herbal medicine, so my friends viewers why wait and be suffer when there is someone like Dr Unuareghe that can cure any disease HIV/ CANCER/ HEPATITIS B VIRUS, you can contact his via:dr.unuareghecuringhome@gmail.com

Angela Jones said...

Hi Friends i am so glad to writing this article today to tell the world how Dr Unuareghe cured my HSV VIRUS,i have been detected with HSV-1 AND HSV-2 since five years ago, ever since then my life has been in complete bizarre and agony,i have used so many drugs that was prescribed to me by several doctors,but it didn't cure my HSV VIRUS neither did it reduce the pain,until a certain i was checking for solution in the internet,then miraculously came across Dr Unuareghe the powerful herbalist that cure numerous individuals HSV-1 AND HSV-2 INFECTION,then i contacted his email: dr.unuareghecuringhome@gmail.com i explained everything to him and prepared a cure that cure my HSV-1 AND HSV-2 disease totally after receiving his herbal medicine, so my friends viewers why wait and be suffer when there is someone like Dr Unuareghe that can cure any disease HIV/ CANCER/ HEPATITIS B VIRUS, you can contact his via:dr.unuareghecuringhome@gmail.com