tag:blogger.com,1999:blog-13900197.post3475776219048568890..comments2023-10-15T05:20:00.675-06:00Comments on Entropy Production: M1 and M2 macrophages and the Herpes-virus familyRobert McLeodhttp://www.blogger.com/profile/05270962906437456350noreply@blogger.comBlogger4125tag:blogger.com,1999:blog-13900197.post-34516977627728590362014-02-02T19:44:11.048-07:002014-02-02T19:44:11.048-07:00The virus may stay where it entered the body or it...The virus may stay where it entered the body or it can move through the blood, inside white blood cells, lymphatic vessels, or nerves.Anonymoushttps://www.blogger.com/profile/14889202147981086655noreply@blogger.comtag:blogger.com,1999:blog-13900197.post-51140284554060990142011-01-19T07:17:48.326-07:002011-01-19T07:17:48.326-07:00Ah yes, I see now. May I ask about your conclusion...Ah yes, I see now. May I ask about your conclusion that:<br /><br />"The prevalence of immune system bodies in the adipose tissue of the obese mice illustrates an example of the, "diseases of civilization," being largely driven by dysfunction of the innate immune system, probably egged on by latent viral and bacterial infections and an unnatural diet. The pieces of the puzzle are mostly there now and evidence will continue to accumulate until we have a better view of the whole picture. Stop the sources of inflammation (i.e. immune system activation), give the immune system the substrates it needs to fight effectively, and the other symptoms will go away. "<br /><br />Here, you suggest that "latent viral and bacterial infections and an unnatural diet" are "pieces of the puzzle."<br /><br />I'm wondering if you've thought about whether latent <i>fungal</i> infections might be various pieces of this puzzle, too, especially where fungi opportunistically decompose an unnatural diet? While useful to decompose an unnatural diet, the fungal growths are also attacked by macrophages,* which (possibly?) leads to obesity, either directly or downstream, through immune system compromise that eventually leads to proliferation of the other latent pathogens, viral and bacterial?<br /><br />Thanks again for the great post, and also for your follow up work!<br /><br />* The fungi are also attacked, as you explained, by *phils.Innovatorhttps://www.blogger.com/profile/06252984695076905280noreply@blogger.comtag:blogger.com,1999:blog-13900197.post-48112088814817748982011-01-12T17:20:59.661-07:002011-01-12T17:20:59.661-07:00Sigh... more spam to delete.
Sorry for the delay ...Sigh... more spam to delete.<br /><br />Sorry for the delay in replying Deep. The article you cited suggests neutrophils fail largely when they are defective, i.e. missing a certain gene, so that's not likely to affect the general population, just rare unfortunate individuals. That said, the *phils and macrophages tend to work together. The *phils are suicide shock troops of the innate immune system while the macrophages tend to mop up what's left. <br /><br />The article you provided is pretty specific on mechanisms but doesn't go into much detail on the topic you are actually interested in.Robert McLeodhttps://www.blogger.com/profile/05270962906437456350noreply@blogger.comtag:blogger.com,1999:blog-13900197.post-33455274319809299592011-01-05T11:27:54.955-07:002011-01-05T11:27:54.955-07:00I accidently deleted a comment by J.A. Deep yester...I accidently deleted a comment by J.A. Deep yesterday when going through the spam:<br /><br /><i>Great to see a post from you, Robert. I'm interested in the role of candidiasis in metabolic syndrome (and hence obesity). I note that mononuclear phagocytes, in some instances in the absence of other professional phagocytes such as neutrophils, also play an import role in resistance to systemic and mucosal candidiasis. <a href="http://mmbr.asm.org/cgi/content/short/61/2/170" rel="nofollow">Cite</a>. Thoughts? Thanks, much. </i>Robert McLeodhttps://www.blogger.com/profile/05270962906437456350noreply@blogger.com