04 October 2012

JAMA Study on Efficacy of Vitamin D in Preventing Colds

Whether or not low vitamin D3 levels can affect how often one can get sick is an interesting line of research these days.  The notion is, we spend so much time indoors or slathered in UVB-blocking sun cream that our bodies aren't producing nearly as much vitamin D3 as they did historically before the industrial age.

A new study in the Journal of the American Medical Association treated a population with vitamin D to see if vitamin D serum levels affect how often a person contracts a respiratory infection (Murdoch et al., 2012, free access). This was a randomized, double-blind study with a placebo group, so it's a high quality study and from my reading appears solid.  75 % of the study participants were female.  The treatment method was to give participants an oral dose of 200,000 IU initially and again one month later.  They then followed that up with 100,000 IU per month for the remainder of the study, which is about 3,300 IU per day.  Personally I take 4,000 IU per day in the winter and none in the summer.

My first concern was whether or not the treatment method, large monthly oral dose vitamin D, especially because vitamin D is fat soluble, the vitamin D was given in tablet form, and there were no instructions to eat fat with the dose that I can find.  However, as shown by Figure 2, they study had no problem creating a statistically significant difference between the treatment and placebo groups.
Figure 2 (from Murdoch et al., 2012): Mean serum levels of vitamin D3 in the treatment and placebo group.  Significantly different levels were achieved in only two months and maintained throughout the study period. 

The authors found no negative effects such as hypercalcemia and no side effects from the high dose regimen.  The fact that the human body does absorb such large doses of vitamin D3 does sort of suggest that the human body really does aim for higher vitamin D serum levels then are present in the general population.

The results show that there was no difference between the high and low serum vitamin D groups on the incidence of respiratory infections or days of work missed.  So that's a big nada for vitamin D supplementation to improve immune system response against these particular viruses.  Interestingly, while the common cold was not heavily affected by vitamin D status, more dangerous respiratory infections such as influenza were statistically significantly reduced,as shown in Table 2.

Table 2 (from Murdoch et al., 2012): Infection rates by common cold associated viruses were unchanged with vitamin D status, but more dangerous flu-like viruses were significantly reduced.
Personally speaking, I fear catching the flu but a cold is barely worth noticing. It is very rare to die from a cold, but influenza and other serious respiratory infections are often lethal in immune system compromised people. The authors noticed this as well,
Of particular note, there were few cases of confirmed influenza infection among our partly vaccinated group of participants. Although adult data are unavailable, a randomized controlled trial in Japanese schoolchildren, set up to assess the effect of vitamin D supplementation on “doctor-diagnosed influenza,” did not report on that outcome but did report a statistically significant reduction in laboratory-confirmed influenza A infection (relative risk, 0.58; P = .04).
There's still plenty of reason to supplement with vitamin D, cancer risk being a big one, but the common cold does not appear to be one of them.

2 comments:

LeonRover said...

Robert,

Thanks for examining this report & making the Table of results available.

I agree with your observation that flu prevention alone is a good reason for Winter supplementation of Vit D in Northern latitudes.

Slainte

George Henderson said...

It was my experience that 3,000 iu vitamin D actually made me more susceptible to cold and flu, but that increasing vit D to 10,000 iu has kept me immune to this kind of infection for the past year and more.
Also, some of the earlier vit D dose was coming from cod liver oil, and this may have been immunosuppressive.
So stopping the CLO when I upped the dose may have helped to some extent.
I question whether anyone should take humungous doses of vit D every month - why don't they study physiological doses, i.e. daily doses that mimic sunlight exposure?